Effects of Propofol Anaesthesia Pre-Medicated with Xylazine on Serum Biochemical Profiles and Sleep Pattern in Red Sokoto Goats

Abstract

This study was conducted with the objective to compare the sleep pattern and biochemical changes during general anesthesia at different timing interval with the baseline information using Propofol as the agent of choice and xylazine as a pre-medicant at 4 mg kg-1 intravenously and 0.025 mg kg-1 intramuscularly respectively. The onset of anaesthesia was rapid (30.1±11.3 seconds), the anaesthetic induction, surgical plane and recovery were good. There was a significant difference (P<0.05) between baseline and other timing intervals in the rectal temperature, respiratory rate, systolic and diastolic blood pressure, but there was no significant difference (P>0.05) in pulse rate. Similarly, a statistically significant difference (P<0.05) was observed in the serum calcium ion, magnesium ion, hydrogen bicarbonate ion, Alkaline Phosphatase (ALP), creatinine, total protein and glucose levels, but there was no significant difference (P>0.05) in the sodium ion, potassium ion, Alanine aminotransferase (ALT), Albumin (ALB), Aspartate aminotransferase (AST), , and Urea. It was concluded that the combination of Propofol and Xylazine at 4mgkg-1 and 0.25mgkg-1 respectively can be effectively and safely used for induction and maintenance of anaesthesia in Red Sokoto goats. It was also noted that recovery was smooth without any violence. The combination was also observed to have minimal effects on the clinico-biochemical parameters of Red Sokoto goats.