Abstract
AbstractThe hemorheological effects of the xanthine derivative propentofylline (HWA 285) were investigated in vitro and ex vivo. The following micromechanical methods were used: (1) Nuclepore filtration test; (2) Filtrometer MF 4 [Teitel, 1977]; (3) Singlepore Erythrocyte Rigidometer (SER) [Kiesewetter et al., 1982b] (4) Mini‐Aggregometer [Schmid‐Schönbein et al., 1973a]. A protective effect of HWA 285, starting at a dose of 10−5 mol/liter, against red blood cell (RBC) rigidification, induced by lactacidosis (pH 6.9) in the Nuclepore filtration test could be demonstrated. RBC deformability was shown to decrease in adjuvant arthritis (AA) in rats. We tested HWA 285 (1, 5.01, 10.0, 15.8, 31.5, and 50.0 mg/kg p.o. for 21 days) in AA rats for its effect on hemorheology. The drug neither had an effect on inflammation with respect to hematological parameters and plasma proteins nor caused a reduction in the increased RBC aggregation in AA rats. However, we could show with the first three methods that HWA 285 has a significant effect on improvement of RBC deformability.
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