Abstract
The aim of this study was to investigate the protective effects of the combined use of probiotic strains on the development of bacterial translocation in addition to liver and intestinal tissue damage due to biliary obstruction in rats. Here, 3 groups each consisting of 10 rats were created:group 1 (sham group), group 2 (obstructive jaundice), and group 3 (obstructive jaundice+probiotic). Groups 1 and 2 were given 1 cc physiological saline solution by oral gavage twice a day; group 3 was given a probiotic solution that included Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Enterococcus faecium, and Bifidobacterium longum microorganisms by oral gavage twice a day. Markers for liver damage were also found to be significantly improved (p<0.05) in the treatment group (group 3). When compared with groups 2 and 3 in terms of liver histology, damage was found to be significantly more severe in group 2 (p<0.01). With regard to ileal villous depth and ileal inflammation, the pathology was found to be significantly more severe in group 2 than that in group 3 (p<0.05). In blood, spleen, and mesenteric lymph node cultures, group 2 showed a microbiological growth rate of 33.8-58.8%, whereas group 3 showed a microbiological growth rate of 14.3-28.6%. This reduction was evaluated to be statistically significant (p<0.05). Our study showed that the combined use of a probiotic in bile duct obstructions reduced bacterial translocation and alleviated pathological changes arising in the liver and terminal ileum histology.
Highlights
Congestion occurring in bile ducts is a life-threatening condition that can be encountered in both children and adults [1]
Our study showed that the combined use of a probiotic in bile duct obstructions reduced bacterial translocation and alleviated pathological changes arising in the liver and terminal ileum histology
The aim of our study is to demonstrate whether multispecies probiotics, which are and cheaply available in the market [15], have an improving effect on bacterial translocation caused
Summary
Congestion occurring in bile ducts is a life-threatening condition that can be encountered in both children and adults [1]. The absence of bile salts that can inactivate endotoxins in the intestine leads to the development of oxidative damage on the intestinal wall [2]. This condition increases the permeability of the intestinal wall by impairing the structure and functions of the intestinal mucosa [2]. Microorganisms in the intestines pass the mucosal barrier and reach the liver, spleen, and mesenteric lymph nodes in the gastrointestinal tract, thereby disrupting the functions of the immune and reticuloendothelial systems [3,4,5,6]. If timely intervention is not exercised, obstructive jaundice can lead to life-threatening clinical pictures due to bacterial translocation [7]
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