Abstract
The effectiveness of probiotic consumption in controlling dyslipidemia in type 2 diabetes mellitus (T2DM) has been unclear. We reviewed relevant randomized controlled trials (RCTs) to clarify the effect of probiotic intake on dyslipidemia in T2DM patients. The Web of Science, Scopus, PubMed and Cochrane Library databases were used for searching relevant RCTs published up to October 2020. The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were selected as the primary indicators for dyslipidemia. The results of 13 eligible RCTs showed that probiotic intake could significantly reduce TC (SMD: −0.23, 95% CI: (−0.37, −0.10)) and TG (SMD: −0.27, 95% CI: (−0.44, −0.11)) levels, but did not regulate LDL-C or HDL-C concentrations. Subgroup analysis showed that multispecies probiotics (≥two species), but not single-species probiotics, significantly decreased TC and TG concentrations. Furthermore, powder, but not liquid, probiotics could reduce TC and TG concentrations. This meta-analysis demonstrated that probiotic supplementation is helpful in reducing TC and TG concentrations in T2DM patients. However, more well-controlled trials are needed to clarify the benefits of probiotics on dyslipidemia in T2DM patients.
Highlights
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by islet beta cell failure and insulin resistance [1]
Dyslipidemia, a large range of lipid abnormalities, may involve a combination of increased total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and TG levels, or decreased high-density lipoprotein cholesterol (HDL-C) level [42]. It is considered as a main risk factor for the occurrence and development of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM) patients [42]
Insulin resistance is a main factor for atherosclerotic CVD, cerebrovascular accident, and peripheral arterial disease [43], which could increase concentrations of plasma TG and LDL-C and reduce concentrations of HDL-C [44]
Summary
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by islet beta cell failure and insulin resistance [1]. It is the most prevalent type of diabetes patients [2]. Foods 2020, 9, 1540 it a serious threat to human health. It has been considered as a major global public health concern due to the increasing number of affected patients and the reducing age of disease onset [6]. Some studies have shown that more than 50% of T2DM patients present with dyslipidemia [7,8]. Dyslipidemia is characterized by an increase in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) concentrations, and a decrease in high-density lipoprotein cholesterol (HDL-C) concentrations, either occurring individually or in various combinations [9]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
