Abstract
Saccharomyces boulardii is a probiotic yeast used as a nutritional supplement. Co-trimoxazole, is a broad-spectrum antimicrobial agent used in the prophylaxis and treatment of infections.The goal of this study was to evaluate the individual and interactive effects of probiotic Saccharomyces boulardii and co-trimoxazole on some haematological parameters in albino rats. Thirty (30) albino Wistar rats weighing 150-200g were divided into five groups; Basal, A, B, C, and D, with six animals in each group. Group A (control) was given a normal rat pellet (standardized feed) and clean water (pH 6.5- 8.5). Group B was administered 5.5mg/kg body weight of the commercial probiotics (Saccharomyces boulardii). Group C was administered 4.4mg/kg body weight of co-trimoxazole. Group D was administered 5.5mg/kg body weight of the commercial probiotics and 4.4mg/kg body weight of co-trimoxazole. All administrations were done using a gavage tube for 15 days. Blood samples were collected for analysis on days 0, 5 and 15. The results showed that Saccharomyces boulardii caused a significant increase (P<0.05) in total white blood cell count and packed cell volume of the treated groups at day 5. On day 15, the total white blood cell count (10.67±0.66), packed cell volume (43.23±0.47), platelet count (932±38.89) and mean platelet volume (8.53±0.38) showed a significant increase (P<0.05) in the probiotic group. The co-trimoxazole group showed a significant reduction (P<0.05) in the packed cell volume and total white blood cell count. This study shows that Saccharomyces boulardii has a positive effect on the haematological profile of the test animals.
Highlights
According to the Food and Agriculture Organization of the United Nations and the World Health Organization, probiotics are living microorganisms that imparts health value to the host when given in ample quantities (FAO/WHO,2002).Disease prevention and treatment as well as enhancing digestion and absorption are some of the beneficial effects it gives to its host (Dahiya et al, 2012)
The findings of this study obtained on Day 5 (Table 1) demonstrated that the animals fed with the probiotic Saccharomyces boulardii recorded a significant increase (P
Was administered both the probiotic saccharomyces boulardii and the antibiotic co-trimoxazole showed significantly higher total white blood cell count compared to Group C which received only co-trimoxazole, indicating cotrimaxazole had no antagonistic effect on the probiotic supplement (Tomicic et al, 2016)
Summary
According to the Food and Agriculture Organization of the United Nations and the World Health Organization, probiotics are living microorganisms that imparts health value to the host when given in ample quantities (FAO/WHO,2002).Disease prevention and treatment as well as enhancing digestion and absorption are some of the beneficial effects it gives to its host (Dahiya et al, 2012). Saccharomyces boulardii was isolated from Lychees fruit (Litchi chinensis) and Mangosteen fruit (Garcinia mangostana) grown in warm tropics in Indochina. It is a eukaryotic, single-cell yeast organism with an optimal growth temperature of 37 degrees Celcius (Niamah, 2017). The metabolic extract of Saccharomyces boulardii was found to inhibit 26 species of food related bacteria (Niamah, 2017). It is can survive gastric acidity and does not change or unpleasantly affect the normal flora in the bowel. Saccharomyces boulardii is resistant to antibiotics naturally and are not affected by sulfamide (Tomicic et al, 2016)
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