Abstract
BackgroundPrevious studies have shown that among women with polycystic ovary syndrome who have difficulties conceiving, frozen-embryo transfer resulted in increased live birth rates and decreased ovarian hyperstimulation syndrome risk than did fresh-embryo transfer. In the present retrospective analysis, we sought to determine the effect of body mass index (BMI) on pregnancy and perinatal outcomes in women with PCOS undergoing FET.MethodsWomen with PCOS (n = 1556) undergoing FET were divided into groups based on weight, with those with normal weight having a BMI of 18.5–24.9 kg/m2,those who were overweight having a BMI of 25–29.9 kg/m2, and those who were obese having a BMI ≥30 kg/m2. Both pregnancy and perinatal outcomes were compared among these groups.ResultsThe normal-weight, overweight, or obese groups exhibited similar pregnancy outcomes, including clinical pregnancy rate, miscarriage rate, ongoing pregnancy rate and live birth rate. In singletons, birth characteristics regarding newborn gender, gestational age, birthweight and length at birth were comparable between the three groups. For adverse neonatal outcomes, the three groups showed no significant differences on the rates of low birthweight, very low birthweight, preterm birth, and very preterm birth after adjustment. In addition, the obstetric complications and the frequencies of live-birth defects were also comparable between the three groups except that overweight and obese women were more likely than women of normal weight to have delivered via cesarean section.ConclusionBMI did not affect the pregnancy or perinatal outcomes in women with PCOS undergoing FET.
Highlights
Previous studies have shown that among women with polycystic ovary syndrome who have difficulties conceiving, frozen-embryo transfer resulted in increased live birth rates and decreased ovarian hyperstimulation syndrome risk than did fresh-embryo transfer
Obesity and Polycystic ovary syndrome (PCOS) are closely-related disorders with overlapping features [23], including possible negative effects on pregnancy or neonatal outcomes. In this large retrospective study of 1680 women with PCOS undergoing Frozen-embryo transfer (FET), we found for the first time women who were overweight or obese did not exhibit any significant differences in obstetric complications, pregnancy or neonatal outcomes such as very Very preterm delivery (PTD), PTD, very Low birth weight (LBW), LBW, macrosomia, smallfor-gestational age (SGA), large-for-gestational age (LGA), or major congenital malformations relative to women of normal weight
We did not find any significant differences in maternal outcome between obese, overweight, and normal weight women undergoing FET, normal weight women had a lower rate of cesarean section in comparison to the other groups
Summary
Previous studies have shown that among women with polycystic ovary syndrome who have difficulties conceiving, frozen-embryo transfer resulted in increased live birth rates and decreased ovarian hyperstimulation syndrome risk than did fresh-embryo transfer. Previous studies have indicated that this freeze-all strategy results in a significant increase in the frequency of pregnancy as well as in live birth rates (LBR), in addition to significantly reducing the risk of ovarian hyperstimulation syndrome (OHSS) which can occur in patients undergoing IVF and ovarian stimulation, potentially leading to death [11, 12]. A randomized clinical trial (n = 1508) of women suffering from PCOS found that FET resulted in significantly increased live birth rates (49.3 vs 42.0%) and decreased OHSS incidence (1.3 vs 7.1%) relative to fresh embryo transfer [13].
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