Abstract
Objective To investigate the effects of preoxygenation on the structure and function of cerebral cortex mitochondria in rats subject to hypoxia-reoxygenation injury.Methods At 20 min before hypoxia,the rats were given rpreoxygenation for 30 min.The mitochondrial membrane fluidity was assayed and the ultrastructural changes of mitochondria were observed under the electron microscopy.Results The brain mitochondrial membrane fluidity was decreased (η and γ were 4.801 ±0.531 and 0.242 ±0.009 respectively) after hypoxia-reoxygenation (η and γ were 2.505 ± 0.837 and 0.182 ± 0.032 respectively,all P＜0.01 ).Preoxygcnation ean increase the brain mitochondrial membrane fluidity increase sequentially (η and γ were 6.217 ± 1.598 and 0.270 ± 0.017 ).The effects of preoxygenation on hypoxia-reoxygenation brain injury were realized by inhibiting the activity of brain adenosine triphosphate (ATP)-sensitive potassium channel.Conclusion Preoxygenation can aggravate the brain injury of hypoxia-reoxygenation. Key words: Preoxygenation; Mitochondria; Brain; Hypoxia reoxygenation injury
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