Effects of preoperative treatment with pulmicort aerosol inhalation combined with low-dose of methylprednisolone on patients with non-small cell lung cancer

Abstract

Objective To investigate the effects of preoperative treatment with pulmicort aerosol inhalation combined with low-dose of methylprednisolone on postoperative pulmonary function and activity of serum TGF-α, VCAM-1, and NK cells in patients with non-small cell lung cancer (NSCLC). Methods From March 2016 to December 2018, 107 NSCLC patients who needed surgical treatment were randomly divided into two groups: observation group (n=54) and control group (n=53). The control group was treated with low dose of methylprednisolone before operation, and the observation group was treated with pulmicort aerosol inhalation on the basis. Pulmonary function, arterial blood gas analysis index, general clinical index, immunological index, and serum transforming growth factor α (TGF-α),vascular cell adhesion molecule-1 (VCAM-1), vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMP)-2, MMP-9 before and after operation, postoperative complications were compared between the two groups. Results After operation, the forced expiratory volume in one second (FEV1), maximal ventilation volume (MVV%), and arterial partial pressure of oxygen (PaO2) in the two groups were higher than those before operation, and the arterial partial pressure of carbon dioxide (PaCO2) was lower than that before operation, the levels of FEV1, MVV%, and PaO2 in the observation group were higher than those in the control group, and the level of PaCO2 was lower than that in the control group (P 0.05). After operation, the percentage of neutrophils (Neu%) and white blood cell (WBC) in the two groups were higher than those before operation, and the Neu% and WBC in the observation group were lower than those in the control group (P 0.05). After operation, the levels of serum TGF-α, VCAM-1, MMP-2, MMP-9, and VEGF in the two groups decreased, and the above indexes in the observation group were lower than those in the control group (P<0.05). There was no statistically significant difference in the incidence of postoperative complications between the two groups (χ2=0.527, P=0.468). Conclusion The preoperative treatment with pulmicort aerosol inhalation combined with low-dose of methylprednisolone can promote the recovery of pulmonary function and blood gas analysis indexes in patients with NSCLC, and help to reduce the levels of serum TGF-α and VCAM-1,promote the recovery of immune function of the body. Key words: Pulmicort; Methylprednisolone; Non-small cell lung cancer (NSCLC); Pulmonary function