Effects of Prenatal Bisphenol-A on Goal-Directed Behavior and Insulin Resistance in Suffolk Sheep

Abstract

Event Abstract Back to Event Effects of Prenatal Bisphenol-A on Goal-Directed Behavior and Insulin Resistance in Suffolk Sheep Nesha R. Jairam1*, Elizabeth M. Peckham2, Vasantha Padmanabhan3 and Theresa M. Lee1, 2 1 University of Michigan, Psychology Graduate Program, Biopsychology, United States 2 University of Michigan, Neuroscience Program, United States 3 University of Michigan, Department of Pediatrics & Molecular and Integrative Physiology, United States Bisphenol-A, an endocrine disrupting chemical that mimics estrogen, is found in commonly used containers. Low doses of exposure in human fetuses are of concern during periods of development. Previous research shows that prenatal BPA exposure elevated the risk of insulin resistance in mice; this current study investigates whether insulin responses are predictive of behavioral responses in tests of goal-directed behaviors in a sheep model. Goal-directed behavior was determined by measuring consumption of palatable food (PFT) and the rate of learning in a conditioned place preference test (CPP), in male and female peripubertal animals exposed to 0.5 mg/kg/day BPA or vehicle daily between days 30-90G. Insulin responses were determined using a glucose tolerance test. Control males demonstrated greater goal directed behavior for food than control females. BPA and control males show no difference in the amount of food consumed in the PFT. BPA females and injection controls (IC) are consuming more food than uninjected control females, 89.77% and 86.09% respectively, which was significantly higher than uninjected control females (57.77%). BPA males and BPA females show no difference in time spent in the conditioned side of a CPP from same-sex controls. There is no effect of BPA on male motivation for food. In females, daily injection of the ewe has masculinized the motivation for food. This study demonstrates the sex differences in food-induced goal directed behavior is not affected by BPA doses commonly found in humans. Acknowledgements NIEHS Grant: R01 ES019189 Reproductive Sciences Program Lee Neuroendocrinology Lab Padmanabhan Lab Stephanie Stout – Lab Technician Alexander Kastl – Lab Technician Celia Upton, Kate Gilliam, and Emily Sheppard References Alonso-Magdalena, P., Vieira, E., Soriano, S., Menes, L., Burks, D., Quesada, I., et al. (2010). Bisphenol A exposure during Pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environmental Health Perspectives, 118(9), 1243-1250. Maffini, M. V., Rubin, B. S., Sonnenschein, C., & Soto, A. M. (2006). Endocrine disruptors and reproductive health: The case of bisphenol-A. Molecular and Cellular Endocrinology, 254, 179-186. Keywords: Behavior, Bisphenol-A, goal-directed, Hormones, Insulin Resistance, prenatal Conference: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology, Ann Arbor, United States, 13 Jul - 16 Jul, 2011. Presentation Type: Poster Topic: Environmental endocrinology Citation: Jairam NR, Peckham EM, Padmanabhan V and Lee TM (2011). Effects of Prenatal Bisphenol-A on Goal-Directed Behavior and Insulin Resistance in Suffolk Sheep. Front. Endocrinol. Conference Abstract: NASCE 2011: The inaugural meeting of the North American Society for Comparative Endocrinology. doi: 10.3389/conf.fendo.2011.04.00146 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Jul 2011; Published Online: 09 Aug 2011. * Correspondence: Miss. Nesha R Jairam, University of Michigan, Psychology Graduate Program, Biopsychology, Ann Arbor, MI, 48109, United States, reddica@umich.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nesha R Jairam Elizabeth M Peckham Vasantha Padmanabhan Theresa M Lee Google Nesha R Jairam Elizabeth M Peckham Vasantha Padmanabhan Theresa M Lee Google Scholar Nesha R Jairam Elizabeth M Peckham Vasantha Padmanabhan Theresa M Lee PubMed Nesha R Jairam Elizabeth M Peckham Vasantha Padmanabhan Theresa M Lee Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.