Abstract
The effects of general anesthesia on the developing brain remain a great concern in the medical field and even in the public, and most researches in this area focus on infancy and childhood. In recent years, with the continuous development of medical technology, the number of operations during pregnancy is increasing, however, studies on general anesthesia during pregnancy are relatively lacking. The mid-trimester of pregnancy is a critical period, and is regarded as a safe period for surgery, but it is a fragile period for the development of the central nervous system and is particularly sensitive to the impact of the environment. Our research group found that general anesthesia may have adverse effects on fetal neurodevelopment during the mid-trimester. Therefore, in this review, we summarize the characteristics of anesthesia during pregnancy, and the related research of the anesthesia’s impacts on the development of central nervous system were introduced.
Highlights
With the development of medical technology, the number of fetus and infant surgery have been increasing
This review introduces the characteristics of anesthetics, the particularity of anesthesia during pregnancy and the effects of anesthetics on the central nervous system during the mid-trimester
The maternal application of muscle relaxants has little or no effect on the fetus, because of their limited placental penetration (Kampe et al, 2003). These results show that the anesthetic transshipment in the maternal and fetus body is a complex pharmacokinetic model
Summary
Edited by: Judith Ann Smith, University of Texas Health Science Center at Houston, United States. Reviewed by: David Bellinger, Boston Children’s Hospital, Harvard Medical School, United States. The effects of general anesthesia on the developing brain remain a great concern in the medical field and even in the public, and most researches in this area focus on infancy and childhood. The mid-trimester of pregnancy is a critical period, and is regarded as a safe period for surgery, but it is a fragile period for the development of the central nervous system and is sensitive to the impact of the environment. Our research group found that general anesthesia may have adverse effects on fetal neurodevelopment during the mid-trimester. In this review, we summarize the characteristics of anesthesia during pregnancy, and the related research of the anesthesia’s impacts on the development of central nervous system were introduced
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