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Abstract
The pressor activity generated in incubated plasma of nonpregnant female and pregnant rats was measured by means of a sensitive bioassay technique. It was found that the plasma incubated for 12 hours on days 7, 14 and 19 of pregnancy generated significantly smaller amounts of the pressor substance than the incubated plasma of nonpregnant rats. Vasopressor activity of the plasma incubated for 12 hours from ovariectomized female rats treated with either estradiol (100 μg/kg), progesterone (2.5 mg/kg), or both were not different from control rats. These results indicate that pregnant rats are characterized by reduced amounts of the vasopressor substance, active pressor principle, and the amount of the principle seems to be regulated by neither estrogen nor progesterone in the rat.
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Schedule a callMore From: Clinical and Experimental Hypertension. Part B: Hypertension in Pregnancy
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