Abstract
The effect of prednisolone on the incorporation of 32P-phosphoric acid into asynchronously and synchronously growing Henle cells was determined. A 24 h exposure of cell cultures to prednisolone was necessary to produce a significant inhibition of total 32P incorporation into the cells. However, less than 1 h exposure to the hormone was sufficient to show an inhibition of 32P incorporation into the lipid fraction. After the separation of the phospholipid components by thin-layer chromatography, it was found that prednisolone caused no significant alteration in the distribution of the 32P label among the phosphatides. The incorporation of 32P into the phospholipid fraction of synchronously growing cells was suppressed by prednisolone during the entire division cycle.
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