Abstract
Abstract High-fat diet leads to obesity-associated chronic low-grade inflammation. Prebiotics, probiotics, and synbiotics produced short-chain fatty acids (SCFA), bonded to G protein-coupled receptors (GPR)-41 and GPR-43 decreased triglyceride deposits in adipocytes and liver, decreased fatty acid oxidation, increased glucose regulation and insulin sensitivity thus reduced the risk of obesity and metabolic syndrome. This study conducted in order to evaluate the effects of prebiotics, probiotics, and synbiotics on the body weight, blood glucose, triglyceride, and TNF-α used rats model, which were fed by a high-fat diet. Thirty-eight 6-8 weeks old male rats were fed by high-fat diet for three weeks, then rats were randomly divided into four groups, high-fat diet (HFD), a high fat diet with prebiotics supplementation (HFD+ PRE), a high fat diet with probiotics supplementation (HFD+PRO), and high-fat diet with synbiotics supplementation (HFD+SYN) for three weeks. Blood samples and body weight were measured at the third and sixth week. There was no effect of prebiotics, probiotics, and synbiotics on body weight, triglyceride levels, blood glucose, and TNF-α in rats fed a high-fat diet compared to control. These results suggested that supplementations gave inconsistent results with other studies and needed further researches.Keywords : high fat diet, prebiotics, probiotics, synbiotics, meta-inflammationCorrespondence : soebagijo@yahoo.com
Highlights
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Summary
2) Department of Internal Medicine, Universitas Airlangga / Dr Soetomo Hospital, Surabaya, Indonesia. 3) Department of Microbiology, Universitas Airlangga / Dr Soetomo Hospital, Surabaya, Indonesia. AARRTTIICCLLEE IINNFFOO Submitted : Januari 2019 SAucbcmepitetded :: JFaenburuaaryry20220019 APcucbelpistheded :: JMuleyi 22001290 Published : July 2020. UTmhiastisctusdeyvecroendburcatiendiinnjuorrydeorftoInedvoalnueastiea stohefaer.ffIencttshiosf cparseebiroetpicosr,t,parombiaoltei,cs4,5aynedasrys noblido,tiwcsasotnaktheen tobotdhye wEemigehrgt,ebnlcoyodIngsltuaclloastieo,ntri(gIRlyDce)riadfete, ranedxpTeNriFen-αciunsgeda traftfsicmaocdceild,ewnht i1ch whoeruersfebdebfoyrea hbiegihn-gfaht odsipeti.taTlihzierdty.-eAigfthetr s6u-r8gewrye,ekthseolsdigmnsaloefradtisawbeetrees fiendsibpyidhuisghw-faast dpireetsefonrtetdhrebey pwoleyeukrsi,athoef n30ra0tcscw/ehreourranudroinmelyprdoidvuidcteidoninatondfo1u4r9gmromuopls,/ Lhihgyhp-efarnt adtireetm(HiaF, Dal)th, oauhgihghthfeatimdimetewdiathtepardebmiointiicstsrasutipopnleo-f dmesemntoaptiroenss(iHn,FtDhe+ PpaRtEie)n,tas hcilginhifcaatldainetdwhiethmpordoybnioatmiciscswupa-s npoltesmhoenwtnataionny (imHFprDo+vePmReOn)t,sa. Tndhehpigahti-efnat pdaiestsewdiathwsayynibniotht-e diacysssfuivpeploefmtreenattamtioent(iHn FthDe+ISnYteNns)ivfeorCtahrreeeUnwiet e(IkCs.UB).loTohde msaaminptlreesatamndenbtsodfyorwdeiiagbhettews eirnesimpiedaussuriendtraatutmheattihcirsdevaenrde bsriaxitnh iwnjeuerky. Cedera otak berat traummaattiiss aaddaallaahh cceeddeerraaffaattaall, dennggann ttiinnggkkaatt kkeemmaattiiaannhhiinnggggaa5500%%. Sekitar 1,5 jjuuta orang mengalami cedera otak berat di Amerika Serikat. Tidak ada data pasti tentang kejjaaddiiaann diabetessiinnssiippiidduussppaaddaappaassiieennddeennggaanncceeddeerraaoottaakkttrraauumatis. QANUN MEDIKA Vol 4 No 2 JULY 2020 QQAANNUUNN MMEEDDIIKKAA VVOOLL.4 .lNnoo MMeeii22001199. Be right after distributed) or Mann Whitney In2d)oAnSetiasrlfiafn)D.gegSpayanUrtbenimoivteiecnrstiotwyf.eArenemstahdeesioblyogmy iaxnidngReanciomnatrtoiolngorfoRupSUaDndDrs. uSpopelteommeon,tMatieodnicaglrFouacp-s bo2t)hSutlatyfifnogDfreeApdaiirerltnaetnmsg.egnat SUoufnpAivpnelermssittheyen.staiotiloongy anwdasReanuismedatiionndeopfeRndSeUnDt tD-ter.stS(oieftdoamtao,wMereedincoarlmFaalcl-y admiunlitsyteorfedAbirylaunsgingga Ua ngiavsetriscitytu. be right after distributed) or Mann Whitney
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