Effects of pre-natal and post-natal exposures to air pollution on onset and recurrence of childhood otitis media

Abstract

BackgroundDespite mounting evidence linking outdoor air pollution with otitis media (OM), the role of air pollutant(s) exposure during which critical window(s) on childhood OM remains unknown. ObjectivesWe sought to identify the key air pollutant(s) and critical window(s) associated with the onset and recurrent attacks of OM in kindergarten children. MethodsA combined cross-sectional and retrospective cohort study involving 8689 preschoolers aged 3–6 years was performed in Changsha, China. From 2013–2020, data on air pollutants were collected from ambient air quality monitoring stations in Changsha, and the exposure concentration to each child at their home address was calculated using the inverse distance weighted (IDW) method. The relationship between air pollution and OM in kindergarten children was studied using multiple logistic regression models. ResultsChildhood lifetime OM was associated with PM2.5, SO2 and NO2, with ORs (95% CI) of 1.43 (1.19–1.71), 1.18 (1.01–1.37) and 1.18 (1.00–1.39) by per IQR increase in utero exposure and with PM2.5, PM2.5–10 and PM10, with ORs = 1.15 (1.00–1.32), 1.25 (1.13–1.40) and 1.49 (1.28–1.74) for entire post-natal exposure, respectively. The 2nd trimester in utero and the post-natal period, especially the 1st year, were key exposure time windows to PM2.5 and PM10 associated with lifetime OM and the onset of OM. Similarly, the 4th gestational month was a critical window for all pollutants except CO exposure in relation to lifetime OM and OM onset, but not recurrent OM attacks. PM2.5 exposure during the nine gestational months and PM10 exposure during the first three years had cumulative effects on OM development. Our subgroup analysis revealed that certain children were more susceptible to the OM risk posed by air pollution. ConclusionsEarly-life exposure to air pollution, particularly PM2.5 during the middle of gestation and PM10 during the early post-natal period, was associated with childhood OM.