Abstract
In this study, liquid plasma treatment was used to improve the morphology of Poly-є-CaproLactone (PCL) NanoFibers (NFs), followed by performing a Dielectric Barrier Discharge (DBD) plasma surface modification to enhance the hydrophilicity of electrospun mats generated from plasma-modified PCL solutions. Cell interaction studies performed after 1 day and 7 days clearly revealed the highly increased cellular interactions on the double plasma-treated nanofibers compared to the pristine ones due to the combination of (1) a better NF morphology and (2) an increased surface hydrophilicity.
Highlights
The application of electrospun nanofibers (NFs) in tissue engineering is increasing owing to their morphological similarity to the ExtraCellular Matrix (ECM) as most of the ECM proteins have a fibrous structure with diameters in the nanometer or sub-micrometer range [1]
Liquid plasma treatment was used to improve the morphology of Polyǫ-CaproLactone (PCL) NanoFibers (NFs), followed by performing a Dielectric Barrier Discharge (DBD) plasma surface modification to enhance the hydrophilicity of electrospun mats generated from plasma-modified PCL solutions
Atmospheric Pressure Plasma Jet (APPJ) treatment of the PCL polymer solution: solution properties and PCL-NF morphology The conductivity and viscosity of the PCL polymer solution before and after APPJ treatment can be found in Table 1: from reported values it is evident that plasma exposure can strongly increase these parameters
Summary
The application of electrospun nanofibers (NFs) in tissue engineering is increasing owing to their morphological similarity to the ExtraCellular Matrix (ECM) as most of the ECM proteins have a fibrous structure with diameters in the nanometer or sub-micrometer range [1]. Liquid plasma treatment was used to improve the morphology of Polyǫ-CaproLactone (PCL) NanoFibers (NFs), followed by performing a Dielectric Barrier Discharge (DBD) plasma surface modification to enhance the hydrophilicity of electrospun mats generated from plasma-modified PCL solutions.
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