Abstract
Lipotoxicity is one of the important reasons of β-cell failure in type 2 diabetes. Lipotoxicity contributes to β-cell dysfunction and apoptosis through a variety of ways and factors, such as ceramide ,endoplasmic reticulum stress, etc. How to prevent or delay the β-cell failure, decreasing the occurrence or development of type 2 diabetes, is an important task. The present studies show that the activation of peroxisome proliferator-activated receptor (PPAR) γ would reverse the pancreatic β-cell lipotoxicity, and thus play a protective effect of pancreatic islet β-cell. Its mechanism includes reducing β-cell apoptosis, regulating lipid metabolism-related gene expression or directly controlling the expression of insulin-related factors, resisting the inflammatory response induced by free fatty acid. Key words: Peroxisome proliferator-activated receptor; Lipotoxicity; Islet β-cell ; Type 2 diabetes mellitus
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