Abstract
Abstract— Effects of an increased concentration of K+ (55 mm) in the medium on fluxes of glutamate and other amino acids in the presence and absence of 10 mm‐glutamate were studied. The following observations were made:(1) The efflux of glutamate is slightly increased by excess K+. The glutamate efflux is smaller than the potassium fluxes.(2) The K+‐induced increase of glutamate efflux is enhanced under anoxia or in glutamate‐containing media.(3) The influx of glutamate is unaffected or slightly increased by excess K+.(4) The efflux of GABA is increased by excess K+, both in the absence and in the presence of glutamate.(5) Efflux of glutamine, leucine and lysine is increased by excess K+, but only provided that glutamate is also present in the medium.(6) Efflux of glutamate and of GABA is increased by addition of 10 mm‐glutamate.
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