Abstract
To determine the possible role of ovarian steroids in the development of sterility in lightly androgenized rats that exhibit the delayed anovulation syndrome (DAS), rats were ovariectomized prepubertally and the ability of steroids to facilitate LH secretion was tested before and after prolonged treatment with oil, estradiol benzoate (EB), or testosterone propionate (TP). The LH response of the animals was compared to that of additional androgenized rats ovariectomized after onset of sterility, as well as to rats given oil neonatally. Female rats given oil (normals) or 10 μg TP (DAS) at 5 days of age were either ovariectomized at 30 days or left intact until 95 days. Rats ovariectomized prepubertally were given EB at 1000 h on day 32, and bled for RIA of plasma LH at 24, 31, and 55 h after EB. Daily injections of oil, EB, or TP were given to the ovariectomized rats for 60 days, beginning on day 35. A blood sample was taken at the end of the injections, and intact rats were ovariectomized at that time. One...
Published Version
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