Abstract

In rhesus monkeys and humans, the effects of dietary taurine deprivation are age-dependent. Infants require a dietary source of taurine to maintain normal plasma and tissue taurine concentrations whereas adults generally do not. In both human and monkey infants, taurine-free infant formulas produce a drop of approximately 50% in plasma taurine concentrations compared to either taurine-supplemented formulas or breast milk, which is rich in taurine. We have examined the effects of dietary taurine deprivation in rhesus monkeys through the first postnatal year in order to define the time course of these effects, their persistence, and the period of vulnerability, particularly with respect to the morphology and function of the retina and central visual system.

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