Abstract
ABSTRACT The effect of the administration of porcine calcitonin together with dietary Ca and P supplements for a period of 3 months to 7 osteoporotic patients was evaluated by means of clinical observation, Ca-balance studies, kinetic tracer studies, and neutron activation analysis. Clinical improvement was evidenced in this study by a decrease in back pain and a cessation of spontaneous fractures. The compartmental analysis and the balance studies indicated a decrease in the resorption rate, and a small increase in the Ca balance. Direct measurement of total body calcium by in-vivo neutron activation analysis also showed a small increase in the calcium concentration in the skeleton of several of the patients. Taken by themselves, the objective data are not highly significant, but together with the clinical findings, they suggest a potential efficacy of calcitonin therapy. The three month period studied appears to be insufficient for the accumulation of significant amounts of calcium. The direction of the...
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