Effects of pomegranate (Punica granatum L.) peel extract supplementation on serum lipid profile and oxidative stress in obese women with knee osteoarthritis: A double blind, randomized, placebo controlled study

Abstract

ObjectiveDyslipidemia and subsequent oxidative stress may be involved in the progression of osteoarthritis (OA). The aim of the study was to investigate the effects of pomegranate peel extract (PPE) supplementation on serum lipid profile and antioxidant status in obese women with knee OA. MethodsThis randomized, double-blind placebo-controlled clinical trial was conducted on 66 obese women aged 38–60 years old with knee OA. Participants were allocated into two groups. Subjects in the intervention group (n = 33) received PPE capsules (500 mg) twice daily for 8 weeks along with standard drug therapy and control group (n = 33) received placebo for the same period. Fasting blood samples, anthropometric measurements, dietary intakes data, and physical activity levels were collected at the baseline and end of the study. ResultsPPE supplementation significantly decreased serum total cholesterol, triglyceride and malondialdehyde levels (all, p < 0.05) and increased erythrocyte superoxide dismutase, glutathione peroxidase and serum total antioxidant capacity compared to the control group at the end of study (p < 0.05). No significant differences were observed between two groups in serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and body mass index at the end of the trial (p > 0.05). ConclusionResults indicated that short term PPE supplementation had useful effects on serum levels of total cholesterol and triglyceride and antioxidant status in obese women with knee OA.