Abstract
Context: Diabetic liver injury is a serious diabetic complication. The alterations of intestinal microbiota play an important role in induction and promotion of liver injury progression. Physalis alkekengi L. var. francheti (Mast.) Makino (Solanaceae) has been used as a water decoction for treating diabetes.Objective: To study the effects of a polysaccharide (PPSB) from Physalis alkekengi var. francheti on liver injury and intestinal microflora in type-2 diabetic mice.Materials and methods: Streptozotocin (160 mg/kg) was injected i.p. for 3 days to build model. The diabetic mice were randomly divided into four groups together with control group (10 mice in each group). The doses of PPSB were 50 and 100 mg/kg, respectively. After 5 weeks administration, level of blood glucose, ALT and AST were measured. Alterations of intestinal microflora, and protein expression of TGF-β1, TNF-α and DCN were detected.Results: Level of blood glucose decreased from (25.38 ± 2.21) mmol/L to (18.01 ± 2.53) mmol/L, ALT and AST decreased to (24.67 ± 4.86) U/L and (30.84 ± 7.50) U/L in PPSB-H group. Lactobacillus, Clostridium butyricum, and Bacteroides increased remarkably with increasing concentration of PPSB, but Enterobacter was inhibited. The relative expression of TGF-β1 and TNF-α decreased to (0.70 ± 0.17) and (0.39 ± 0.06), and the expression of DCN increased to (0.65 ± 0.13).Discussion and conclusions: Probiotics have been promoted by PPSB, and protein expressions have been modulated in the progression of liver injury. PPSB could be used as a natural agent for treating diabetic liver injury and intestinal microflora imbalance.
Highlights
Diabetes is a serious endocrine disorder causing morbidity and mortality worldwide
Probiotics have been promoted by PPSB, and protein expressions have been modulated in the progression of liver injury
According to the recent Diabetes Atlas produced by the International Diabetes Federation (IDF), China is home to the largest number of people with diabetes in the world, 109.6 million diabetic subjects were found in China in 2015, and these numbers are predicted to increase to 150.7 million by 2040
Summary
Diabetes is a serious endocrine disorder causing morbidity and mortality worldwide. It has become the 3rd most common chronic disease harmful to human health, after tumours and cerebrovascular diseases. According to the recent Diabetes Atlas produced by the International Diabetes Federation (IDF), China is home to the largest number of people with diabetes in the world, 109.6 million diabetic subjects were found in China in 2015, and these numbers are predicted to increase to 150.7 million by 2040. Diabetes needs long-term control by drugs; its increasing prevalence has put a large burden on society (Zhao et al 2012). The chemical drugs used have some serious adverse reactions, such as hypoglycaemia, anaphylactic shock, liver damage, and cardiovascular toxicity (Xiao et al 2011). The natural extracts/components have been paid more attention due to the fewer side effects or no harm to human bodies
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