Effects Of Polyphenols Supplementation On Inflammation And Oxidative Stress After Acute Exercise: A Systematic Review And Meta-analysis

Abstract

Polyphenols are plant-based bioactive compounds that demonstrate antioxidant and anti-inflammatory properties. Acute exercise works as a stressor on body tissues, leading to inflammation and oxidative stress. PURPOSE: The purpose of the study is to determine the effects of polyphenols supplementation on inflammatory and oxidative stress markers after acute exercise. METHODS: A systematic review with meta-analysis was performed to evaluate the effects of polyphenols supplementation on inflammatory and oxidative stress markers post-acute exercise. PubMed was searched using key words “polyphenol inflammation exercise” and “polyphenol oxidative stress exercise”. Outcome measures included inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-α, and oxidative stress marker malondialdehyde (MDA). Outcomes were compared by calculating standardized mean difference (SMD) and 95% confidence intervals (CI). RESULTS: The total number of articles identified to be included in the study for quantitative synthesis were 14, including 10 studies on “polyphenol inflammation exercise” with 274 subjects, and 4 studies on “polyphenol oxidative stress exercise” with 76 subjects. The results showed IL-6 (SMD -0.58, 95% CI -0.88 to -0.29, P < 0.01) and MDA (SMD -1.34, 95% CI -1.86 to -0.82, P < 0.01) levels were significantly lowered with polyphenols supplementation after acute exercise. However, polyphenols supplementation did not affect CRP (SMD -0.12, 95% CI -0.42 to 0.19, P = 0.60), IL-8 (SMD -0.12, 95% CI -0.36 to 0.13, P = 0.31) and TNF-α (SMD 0.15, 95% CI -0.19 to 0.50, P = 0.44) levels after acute exercise. CONCLUSIONS: Polyphenols supplementation could reduce inflammatory marker IL-6 and oxidative stress marker MDA induced by acute exercise.