Abstract
Aryl hydrocarbon hydroxylase (AHH) has been measured as benzo(a)pyrene hydroxylase in the intestine and liver of rats and mice treated with a single dose of different polyhalogenated aromatic hydrocarbons. Maximal stimulation of liver AHH activity is reached with a dose of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) half as great as that necessary for maximal stimulation of the intestine. The duration of the effect of TCDD on intestinal AHH differs from the constant increase that occurs in the liver. Although the magnitude of the stimulation by 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT) is less than that of TCDD, the qualitative changes in intestinal and liver AHH are similar. The changes in activity of intestinal and hepatic AHH were not directly correlated in the tissues of rats treated with several other polyhalogenated aromatic hydrocarbons. Liver and intestinal AHH activity were affected differently by fasting. These results suggest that AHH activity in the intestine and liver has different control mechanisms.
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