Effects of Polygonum Cuspidatum Total Anthraquinone on Diabetic Mice Model

Abstract

objective: effects of Polygonum cuspidatum total anthraquinone on streptozotocin induced diabetic mouse model, To investigate the hypoglycemic mechanism and characteristics of Polygonum cuspidatum anthraquinone. Method: By intravenous injecting streptozotocin induced diabetic mice model, detecting the serum glucose, glycosylated serum protein content, observing the pancreas pathological changes, Studying Polygonum cuspidatum on blood glucose in the mice pancreas. Result：Successful established diabetic mice model. Compared with model group, The metformin group, high, medium and low doses Polygonum cuspidatum total anthraquinone can reduce the blood sugar and glycosylated serum protein level in diabetic model mice at different levels(P<0.01, P<0.05), and increased liver glycogen, To inhibit the atrophy, necrosis, dissolution and degeneration of pancreatic islet cells in mice. Conclusion: Polygonum cuspidatum total anthraquinone has the effects of reducing blood sugar, glycosylated serum protein level and reducing blood fat, Promoting insulin secretion and hepatic glycogen formation, improve insulin resistance, Improving the pathological changes of pancreas in diabetic mice, It has a good hypoglycemic effect, delayed the process of diabetes to some extent.