Effects of pleasant sound on overnight sleep condition: A crossover randomized study

Abstract

It is desirable to improve sleep quality since poor sleep results in decreases in work productivity and increases in risks of lifestyle-related diseases. Sleep spindles in sleep EEG are waveforms that characterize non-REM sleep Stage 2 (Stage N2). Music therapy has been adopted as a non-pharmacological therapy for sleep quality improvement; however, few studies mention the relationship between music during sleep and spindles. We conducted a crossover randomized study to investigate music's effects on spindles and sleep parameters. Polysomnography (PSG) was performed on 12 adult males with sleep difficulties over three nights, during which they were exposed to three different acoustic environments–silent, white noise, and pleasant sounds–throughout the night, in a crossover randomized setting. Half of the participants with large WASO were defined as the sleep maintenance difficulty group. We investigated whether pleasant sounds shortened sleep onset latency (SOL) and increased the number of spindles (SN) and spindle density (SD) compared to white noise, using silent as the reference. The spindles were detected using the previously reported automatic spindle detection algorithm. After one patient was excluded due to data corruption, a total of 11 participants, including the sleep maintenance difficulty group (n = 5), were analyzed. For all participants, SOL was not significantly shorter with pleasant sound than with white noise (p = 0.683); for the sleep maintenance difficulty group, SOL tended to be shorter with pleasant sound than with white noise (p = 0.060). Compared to white noise, the SN increased in pleasant sound for 7 of 11 (4 of 5 in the sleep maintenance difficulty group), and SD increased for 5 of 11 (3 of 5 in the sleep maintenance difficulty group). The results suggest that all-night background sound exposure may affect SN and SD. Future research should investigate whether background sound exposure reduces sleep-related distress, achieves sound sleep, or improves daytime psychomotor function.