Effects of plateletpheresis on hematological parameters

Abstract

Apheresis for platelet concentrates has been used more frequently in recent years due to the rising demand for platelet transfusions for patients with various medical and surgical disorders. Studies on the effect of repeated or frequent plateletpheresis on the donor's hematological parameters are still limited. This article will review the effects of plateletpheresis on the donor's hematological parameters to define the proper deferral for repeat donation because this treatment is relatively new and requires early repeat donations. We systematically search the studies and review current evidence about the effects of plateletpheresis on blood parameters in healthy donors. Literature tracking was performed on PubMed, CENTRAL, EbscoHost, and ProQuest databases. There are different effects, and some studies reveal that plateletpheresis can decrease hematological parameters (HB, HCT, PLT, PDW). Some can cause an increase in hematological parameters (HB, HCT). These different effects can be caused by variable cell separator technologies, residual blood volume lost during apheresis, and mechanical hemolysis of blood in tubes by machine pumps.