Effects of platelet-rich plasma on repair of skin defects

Abstract

Objective To observe the effects of platelet-rich plasma (PRP) on repairing skin defects in New Zealand rabbits. Methods Whole-thickness skin defects of 3 cm × 3 cm were created at the lef tand right sides of the back of 16 New Zealand rabbits, weighing 2. 5 to 3.0 kg. One side was randomly chosen as the experimental side, which was covered with PRP gel, while the other side was the control one, which was covered with blood gel. 3M film was used to cover the wounds postoperatively. After 5, 10, 15, and 20 days, gross and histological observations were performed to investigate the wound healing at the 2 sides.Results Inflammatory exudate from the wounds and a small amount of purulent exudate from 2 wounds were seen at the control sides 5 days after operation. The wounds at the PRP sides were dry in the same period.From 5 to 20 days, wounds at both sides contracted gradually, but more rapidly at PRP sides, with significant differences between the 2 groups. After 20 days, the wound skin at PRP sides was more mature than at the control sides. Conclusion PRP is effective in repairing skin defects, and can accelerate wound healing. Key words: Skin; Wounds and injuries; Platelet; Plasma; Growth substances