Effects of platelet-rich fibrin on skin pedicle graft healing

Abstract

Objective: Avulsion injuries mostly lead to serious lesions. and those wounds become a challenge to be repaired by surgeons. The aim of the study was to evaluate the effect of autogenic PRF on skin pedicle graft to treat experimental avulsion wounds including clinical and hydroxyproline evaluations. Materials and methods: The experiment was performed on 15 adult female goats, aged between 7-8 months and weighted 18-20 Kg. Surgery was performed under heavy sedation and complete aseptic conditions, 2 skin marks (2×2 cm) were created on both sides of the trunk region of the animal. Two full thickness of the marked skin is cut carefully. A sliding flap (2×6 cm) are harvested parallel to the lines of least tension and are then slid over the adjacent wound which were closed by 2-0 nylon monofilament suture. These wounds are classified into two groups, the first one as the control group and the second group treated with autogenic platelet-rich fibrin. The two groups are represented in each goat. Results: Clinical examination showed the amount of wound exudation in the treated group was a significant increase compared to the control group.