Abstract
Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.
Highlights
The risk of further alveolar bone loss and the probability of tooth loss increases with the presence of intra-bony defects
The inclusion criteria of the study were as follows: no systemic diseases; a good level of oral hygiene (OH); presence of two paired, two- or three-wall intra-bony defects with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm, as detected on radiographs; no intra-bony defects extending into the furcation area; tooth mobility ≤1; tooth and adjoining teeth testing vital and without symptoms or signs of endodontic involvement; and tooth and adjoining teeth free of caries or inadequate restorations
Of the 30 screened patients, 21 eligible participants who provided consent were randomised into test (n = 21) or control (n = 21) groups and 15 patients completed the study (7 women and 8 men; age: 38–61 years)
Summary
The risk of further alveolar bone loss and the probability of tooth loss increases with the presence of intra-bony defects. Is a widely researched and well-documented grafting material.[1] ABBM is produced by removal of all organic components of cancellous or cortical bovine bone. It can be safely used as no systemic or local immune response was observed after ABBM implantation.[2] Histologically, new bone, cementum and new periodontal ligament formation have been observed in periodontal defects treated with ABBM.[3,4] Considering its aforementioned properties, ABBM has been successfully used in regenerative treatment of intra-bony and furcation defects.[1,5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
