Abstract
Objective To investigate the effect of glycosylated hemoglobin A1c (HbA1c) on carotid atherosclerosis in relatively healthy elderly Chinese people. Methods A total of 1863 relatively healthy Chinese people (≥50 years old) were randomized enrolled from the Guangzhou Biobank Cohort Study (GBCS). Personal general historiy was collected before the study in all object. The blood pressure, fasting glucose, lipids, HbA1c and common carotid artery intima-median thickness (CCA-IMT) were measured respectively. After adjustment relevant confounding factors, analysis of convariance was used for continuous variable analysis. Results (1)After adjusting for age, sex and fasting glucose, mean CCA-IMT were increased significantly with the increase of HbA1c level in all participant (P=0.005). The results of linear regression models show that, HbA1c levels was positively associated with mean CCA-IMT after adjusting for age, sex, smoking, physical activity, waist circumference, systolic and diastolic blood pressure, triglyceride, high-density, low-density lipoprotein cholesterol and fasting glucose (regression coefficient t=0.014, P=0.03). Compared to the optimal group (HbA1c 7.5%) were 1.62(1.10, 2.38)and 1.76(0.86, 3.63)respectively(P for trend=0.01). Conclusions Increasing HbA1c level is an independent risk factor for carotid atherosclerosis; that HbA1c-lowering treatment may be an important means for preventing the progression of carotid atherosclerosis. Key words: Hemoglobin A, glycosylated; Carotid artery disease
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