Effects of Plant Essential Oils on Vitamin C, Malondialdehyde and Some Biochemical Parameters of Rats*

I Göze,H Aydin,E Dönmez,S Erşan,N Ercan

doi:10.1590/1806-9061-2018-0754

Abstract

ABSTRACT The aim of this study was to determine the LD30 values of the essential oils of Origanum minutiflorum He Schwarz-PH Davis (OM) and Juniperus excelca by Bieb.subsp. Excel (JE) in vivo investigation on the effects of malondialdehyde (MDA), vitamin C and some biochemical parameters. In this, study the essential oils of OM and JE plants were used. LD50 values of the essential oils were determined by using rats. OM (n=10), JE (n=10), carvacrol (n=10) which dissolve in olive oil were used as experimental group and as control group saline (SF) (n=8) and solvent Olive oil (n=10) were used and applied intraperitoneal on rats for 12 days in LD30 dosages. In the end of 12 days, Vit-C, malondialdehyde (MDA) and routine biochemical analyses were studied on their heart bloods. The difference in the levels of MDA and Vit-C was found significant among the groups (p 0.005). When the values are put to paired comparison, the differences between groups were found statistically significant (p<0.005).OM and JE has led to significant changes in all lipid peroxidation and enzyme levels.

Highlights

Different types of plant extracts have already been studied, essential oils of plants have recently attracted the attention of researchers due to their antimicrobial and antioxidant characteristics for possible use for pharmaceutical purposes and as preservatives for fresh and processed foods (Sökmen et al, 2004).The genus Origanum belongs to the Lamiaceae family, and has 41 species representing 52 taxa globally, and 23 species representing 32 taxa in Turkey (Başer, 2002)
Origanum minutiflorum O Schwarz-PH Davis (OM) is found worldwide and it is an endemic species in mountainous regions of Turkey, where it is commonly used in folk medicine (Baydar,2005; Davis et al, 1998)
The OM (CUFH Voucher No ED11003) plants and Juniperus excelca Bieb.subsp.excelca (JE) (CUFH Voucher No ED11003) fruits received from Sütçüler district of Isparta province were dried under suitable conditions and the essential oils of this plant and fruits were obtained by water vapor distillation in aclevenger apparatus

Summary

Introduction

The genus Origanum belongs to the Lamiaceae family, and has 41 species representing 52 taxa globally, and 23 species representing 32 taxa in Turkey (Başer, 2002). The most common chemical component of Origanum spp. essential oil is carvacrol (Kirimer et al, 1995; Başer, 2002; Baydar, 2005). Origanum has been found to have antimicrobial (Vardar-Ünlü et al, 2007), antigenotoxic (Ipek et al, 2005), antibacterial, antifungal, and anti-angiogenic properties (Paster et al, 1995; Göze et al, 2016). It is used in the pharmaceutical, cosmetic, and soap industries (Farag et al, 1989; Souleles, 1991)

Objectives

Methods

Results