Abstract
1. Core temperature was telemetrically measured in 15 rats before (i.e., at baseline) and at 10-min intervals for 120 min following the injection of normal saline (1 ml/kg ip) or “no injection.” 2. The sample exhibited a mean temperature increase of 0.60 ± 0.10°C(mean ± SEM) following injection. 3. This differed significantly from the mean increase of 0.13 ± 0.03°C following “no injection” (p < 0.001). 4. The injection of saline (1 ml/kg) affected a mean rise in core temperature of 0.55 ± 0.07°C (p > 0.000001) in 46 animals in a second experiment. 5. These data indicate that routine handling and a simple injection comprise significant and measurable stress which must be controlled in neuropharmacological studies employing a thermoregulation paradigm.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
