Abstract
Pingyanymycin (PYM), and antitumor-antibiotic complex which belongs to the belomycin family can induce “G 2-free chromatin” and “uncompleted-packing-mitotic figures” (UPM) at increased frequency after treatment of cultured human lymphocytes. PYM can also induce an extraordinarily high frequency of chromosomal breaks but few sister-chromatid exchanges (SCE) in the same experiment, which is similar to the action of bleomycin. To solve this remarkable contradiction we presume that the UPM is related to a basic mechanism for producing chromosomal aberrations. Pur results also show that various steps of the chromosomal cycle can be affected by certain chemical agents, and these treatments lead to chromosomal aberrations. Thus, other testing systems should be used in addition to the SCE system.
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More From: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
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