Abstract
The behavioural effects of physostigmine (0.02–0.10 mg/kg) were studied using the acquisition of a position discrimination in rats. The drug affected performance when administered before the training or test session, but failed to affect performance on the test session when administered before or immediately after the training session. Small doses of physostigmine (0.02 and 0.06 mg/kg) were shown to bring about an improvement in performance, while a larger dose (0·10 mg/kg) was shown to bring about an impairment. The effects of other acetylcholine-related drugs were then studied. The results suggested that the changes in performance brought about by the cholinesterase inhibitor were related to its effects on central cholinergic transmission. It was argued that the results support the hypothesis that cholinergic transmission is involved in mechanisms of response inhibition and that acetylcholine-related drugs do not affect the processes of learning or memory.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
