Abstract
The aim of this study was to evaluate the cardiovascular autonomic control in trained youth male rats fed with high fructose diet. Weaned male Wistar rats (21 days) fed with fructose in drinking water (10%, 8wks) were randomized into sedentary (FS, n=5) and trained (FT, n=8), treadmill running,5 days/w, 60 min/d, during 8 wks) groups. Insulin resistance was evaluated by Glucose Tolerance Test. Arterial pressure signals were recorded using a data acquisition system (Windaq, 2KHz) in conscious and freely animals. Vagal and sympathetic tonus were measured by pharmacological blockade. The FT group had higher exercise capacity and lower insulin resistance compared to the FS group. Mean arterial pressure was similar between groups (FS: 124 ± 6 vs. FT: 125 ± 3 mmHg), however, the FT group presented resting bradycardia (339 ± 10 bpm) compared to the FS group (366 ± 13bpm). The sympathetic tone was lower in the FT group (41 ± 13bpm) compared to the FS (80 ± 6 bpm), however vagal tone was similar between groups. Thus, our results suggest that physical training during lifespan can be effective in attenuating the autonomic dysfunction resulting from high fructose consumption.
Published Version
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