Abstract
The enhancing effect of hydrophilic groups of phospholipids on the percutaneous penetration of indomethacin (IM) in vitro was examined in a Franz-type diffusion chamber using dorsal skin of guinea pigs. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA) and sphingomyelin (SM) were used as phospholipids. The enhancing effects of these phospholipids on the percutaneous penetration of IM through the skin were in the following order: PG > PE > PC > PS > PA > PI > control > SM. In the experiment of pretreatment with phospholipids, PC, PE and PG significantly enhanced the percutaneous penetration of IM. In the skin without stratum corneum, percutaneous penetration of IM was not significantly affected by PG, PE, PC or SM; however, it was slightly suppressed by SM. These results suggest that phospholipids have a direct influence on the lipid bilayer of the cell membrane in the stratum corneum and the enhancement of percutaneous penetration of IM by phospholipids is due to the alteration of permeability by the interaction of the cell membrane with phospholipids in the skin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
