Effects of phentolamine on haemodynamics of patients with severe sepsis

Abstract

Objective: To explore the effects of phentolamine on hemodynamic of patients with severe sepsis . Methods: From January 2015 to August 2016, using random number table, 59 patients with severe sepsis were divided into research group and the control group by conventional treatment in Department of Emergency, the Second People's Hospital of Nanning City. The patients of the research group were given phentolamine injection. The CI, ITBVI, EVLWI, SVRI of the patients were monitored by PICCO on 6, 12, 24, 48, 72 h before and after treatment. Measuring clearance of blood lactic acid, lactic acid, comparing two groups of blood lactic acid, lactic acid clearance change tendency, 28 d survival rate and time of the two groups in the ICU of patients was observed. Results: CI, SVRI, ITBVI of the research group was increased obviously, and EVLWI decreased obviously(P<0.05 or P<0.01)12, 24, 48, 72 h after treatment. The levels of blood lactic acid, lactic acid clearancef the research group improved better than that of the control group(P<0.05 or P<0.01) after treatment of 12, 24, 48, 72 h time points, especially lactate clearance increased significantly than the control group[(27.2±2.2) mmol/L vs(13.9±3.0) mmol/L, t=8.322, P=0.034]on 6 h. Time in ICU and 28 days rate of the research group was less than the control group[(9.8±3.6)d vs(13.0±4.1)d, P=0.004 ; (22.6% vs 35.7%, P=0.021)]. Conclusion: Phentolamine can significantly improve the early condition of hemodynamic and the survival rates of patients with severe sepsis.