Abstract
Prostaglandin (PG) synthesis from [1- 14C]-arachidonic acid by bovine dental pulp microsomes was stimulated, by 0.1–0.5 mM concentrations of p-chlorophenol (PCP) and inhibited by more than 3 mM. Dual effects (stimulation and inhibition) of phenol, PCP, o-, m-, p- and tri-cresol on PG synthesis by rabbit kidney medullary microsomes were observed. Of various compounds tested, eugenol, thymol and guaiacol were the most potent inhibitors; the inhibitory action was reversible. Phenolic compounds did not affect the activity of glucose-6-phosphatase, adenosine triphosphatase, or lactate dehydrogenase in rabbit kidney medulla within the range of concentrations that stimulated or inhibited PG synthesis. Thus the analgesic effect of phenolic medicaments in endodontic therapy may be due to inhibition of arachidonic-acid metabolism.
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