Abstract
Background Phenolic acids and their derivatives are widely distributed in plants. A series of phenolic acid esters and amides have been synthesized. Methods We determined the effects of phenolic acid derivatives on antiinflammatory activity against phorbol 12-myristate 13-acetate (PMA) and N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced production of superoxide anion, an inflammatory mediator produced by neutrophils. Results When the cells were preincubated with phenolic acids and their derivatives, the superoxide generation induced by fMLP (1.0 μmol/l) and PMA (0.16 μmol/l) was inhibited to various degrees with compounds 1, 2 and 4 significantly suppressing such generation in a concentration-dependent manner. Conclusion Phenolic acid derivatives may exert their antiinflammatory action through inhibiting superoxide generation.
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