Abstract
Effects of PGE 1 or PGE 2 on luteal function were studied in 163 pseudopregnant rats. PGE 1 (10, 100, or 300μg) given intrauterine every 6 hr did not shorten pseudopregnancy (P < 0.05), however, the same doses of PGE 2 given intrauterine every 6 hr advanced luteolysis (P < 0.05). PGE 1 (100 or 300μg) given every 4 hr intramuscular maintained levels of progesterone in peripheral blood above controls (P < 0.05) while 100 or 300μg of PGE 2 hastened the decline in progesterone (P < 0.05). The antiluteolytic effect of PGE 1 was not via an inhibition of PGF secretion (P < 0.05) by the uterus or by induction of ovulation in treated animals. Moreover, PGE 1 (100, 200, or 500μg) given intramuscular every 4 hr from day 4 of pseudopregnancy until the next proestrus delayed luteal regression around 3 days (P < 0.05). PGE 2 at doses of 100, 200, or 500μg every 4 hr given intramuscular consistently shortened pseudopregnancy (P < 0.05). Lower doses were without effect (P < 0.05). Based on the above data it is concluded that PGE 2 is consistently luteolytic whereas PGE 1 is not luteolytic in pseudopregnant rats and that PGE 1 may be an antiluteolysin.
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