Abstract
The study concerned the effects of PGE 1 and PGF 2α and the spontaneous tone and the responses to field stimulation of isolated strips from: lower esophageal spincter (LES), pyloric sphincter (PS) and ileocaecal sphincter (ICS) of cats. PGE 1 and PGF 2 (0.3 μM) increased the LES tone and abolished the PS contractions. PGF 2α increased the tone of ICS while PGE 1 had no effect at all. The effects of the prostaglandin (PG) were reduced when the preparations were pretreated with atropine, propranolol and phenoxybenzamine (1 μM). (1 μM). PGE 1 and PGF 2α decreased the LES relaxation in response to field stimulation (0.5 msec, 2 Hz for 10 sec at supramaximal current). No responses of PS to field stimulation were observed after PG treatment. PGF 2α increased the amplitude of the relaxation response in the ICS to field stimulation. PGE 1 did not change the effect of field stimulation in ICS. The effects of PGE 1 and PGF 2α on the LES and ICS responses to field stimulation were not influenced by adrenergic and cholinergic blocking agents. The data suggest a PG effect on non-adrenergic, non-cholinergic (purinergic) transmission in the gastrointestinal sphincter smooth muscle on field stimulation. Due to the high concentration of PG used this effect was probably a pharmacological one.
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