Abstract

Contributors vii 1. Introduction: Why Should We Care about Organic Chemicals and Human Health? 1 David O. Carpenter 2. Sources of Human Exposure 8 Marti Nadal and Jose L. Domingo 3. The Burden of Cancer from Organic Chemicals 26 Molly M. Jacobs, Rachel I. Massey, and Richard W. Clapp 4. Carcinogenicity and Mechanisms of Persistent Organic Pollutants 57 Gabriele Ludewig, Larry W. Robertson, and Howard P. Glauert 5. Diabetes and the Metabolic Syndrome 101 Duk-Hee Lee and David R. Jacobs, Jr. 6. Mechanistic Basis for Elevation in Risk of Diabetes Caused by Persistent Organic Pollutants 130 Jerome Ruzzin 7. Cardiovascular Disease and Hypertension 143 Marian Pavuk and Nina Dutton 8. Obesity 174 Eveline Dirinck, Adrian Covaci, Luc Van Gaal, and Stijn Verhulst 9. Effects and Predicted Consequences of Persistent and Bioactive Organic Pollutants on Thyroid Function 203 Stefanie Giera and R. Thomas Zoeller 10. An Overview of the Effects of Organic Compounds on Women s Reproductive Health and Birth Outcomes 237 Susan R. Reutman and Juliana W. Meadows 11. Effects of Organic Chemicals on the Male Reproductive System 315 Lars Rylander and Anna Rignell-Hydbom 12. Effects of Endocrine-Disrupting Substances on Bone and Joint 332 Chi-Hsien Chen and Yueliang Leon Guo 13. Organic Chemicals and the Immune System 362 David O. Carpenter 14. Exposures to Organic Pollutants and Respiratory Illnesses in Adults and Children 384 Krassi Rumchev, Jeff Spickett, and Janelle Graham 15. Cognitive Function 400 Lizbeth Lopez-Carrillo and Mariano E. Cebrian 16. Intellectual Developmental Disability Syndromes and Organic Chemicals 421 David O. Carpenter 17. Mechanisms of the Neurotoxic Actions of Organic Chemicals 448 David O. Carpenter 18. Parkinson s Disease 471 Samuel M. Goldman 19. Psychiatric Effects of Organic Chemical Exposure 514 James S. Brown, Jr. 20. Growth and Development 532 Lawrence M. Schell, Mia V. Gallo, and Kristopher K. Burnitz 21. How Much Human Disease Is Caused by Exposure to Organic Chemicals? 557 David O. Carpenter Index 570

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