Effects of peroxyacetyl nitrate alone and in combination with ozone in healthy young women.

Abstract

Metabolic and pulmonary functions were investigated in 10 nonsmoking, young adult women who were exposed for 2 h (21 °C WBGT) to four conditions: 1) filtered air (FA), 2) 0.27 ppm peroxyacetyl nitrate (PAN), 3) 0.48 ppm ozone (O3), and 4) 0.48 ppm O3 + 0.27 ppm PAN (PAN/O3). The subjects alternated 15-min periods of rest and 20-min periods of bicycle ergometer exercise eliciting a of 25 L. Functional residual capacity (FRC) was determined preand post-exposure. Forced vital capacity (FVC) was determined before and after exposure, as well as 5 min after each exercise period. Heart rate was monitored throughout the exposure, and metabolic functions were measured during the last 2 min of each exercise period. There were no changes in any variable consequent to FA or PAN exposure. During O3 and PAN/O3 exposures, a decrease in V T, a concomitant increase in f R, and no change in occurred. Both O3 and PAN/O3 induced significant (p < 0.05) decrements in FVC, FEV1.0, FEV2.0, FEV3.0, FEF25-75%, IC, ERV, and TLC, bu...