Abstract
Peripherally administered, the 5-HT 2 receptor agonist, α-methyl-5-hydroxytryptamine (α-methyl-5-HT), significantly suppressed the food intake of food-deprived rats. α-Methyl-5-HT also inhibited 2-deoxy- d-glucose-induced hyperphagia in rats. The α-methyl-5-HT-induced hypophagia was antagonized by the 5-HT 2A receptor antagonist, ketanserin. The α-methyl-5-HT-induced decrease in food intake of food-deprived rats was not inhibited by prior adrenodemedullation. The peripheral 5-HT 3 receptor agonist, 2-methyl-5-HT, did not affect food intake in food-deprived or 2-deoxy- d-glucose-treated rats. These results suggest that the peripheral 5-HT 2A receptor may participate in the regulation of food intake and that its hypophagic effects are not associated with its adrenaline-releasing effects from the adrenal gland. Lastly, the peripheral 5-HT 3 receptor did not participate in feeding control.
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