Effects of perioperative nutritional risk scores on postoperative clinical outcomes in patients with glioblastoma multiforme

Abstract

Objective To analyze the effects of perioperative nutritional risk scores on postoperative clinical outcomes in patients with glioblastoma multiforme (GBM) . Methods Totally 72 patients with GBM treated in Beijing Tiantan Hospital, Capital Medical University between December 2018 and July 2019 were selected. Their clinical data were retrospectively analyzed. The subjects were divided into high-risk (>5 points, n=34) and low-risk (≤5 points, n=38) groups according to the scores of Nutritional Risk Screening (NRS 2002) . Chi-square test was used to analyze the relationship between nutritional risk and patients' clinical pathological characteristics. Univariate and multivariate Cox regression analyzes were used to analyze the risk factors affecting patients' prognosis. Kaplan-Meier survival analysis and Log-rank test were employed to the difference in survival time between high-risk and low-risk groups. Results Chi-square test revealed that there was statistically significant difference in nutritional risks between patients with methylated an unmethylated MGMT promotor, with and without radiotherapy, and with and without chemotherapy (P 5) was shorter than that of the low-risk group (NRS 2002 score≤5) (P<0.05) . Univariate and multivariate Cox regression analyzes showed that high nutritional risk scores were the risk factor to the prognosis of patients with GBM (P<0.05) . Conclusions Perioperative nutritional risk scores in patients with GBM may serve as a useful indicator for predicting the postoperative clinical outcome of these patients. Key words: Perioperative period; Glioblastoma multiforme; Nutritional status; Nutritional risk; Clinical outcome