Abstract
BackgroundStudies have demonstrated that periodontal disease is associated with the development of systemic complications in patients with type 2 diabetes mellitus (T2DM). The purpose of this pilot study was to investigate which markers among various systemic disease parameters are affected by periodontal treatment in patients with T2DM.MethodsTwelve patients with T2DM were given oral hygiene instructions and subsequent subgingival scaling and root planing. The periodontal status was recorded, and blood and urine samples were taken to measure various parameters of glucose control and systemic status at baseline and 1 month following the periodontal treatment. Serum concentrations of tumor necrosis factor-α and high-sensitivity C-reactive protein were measured by enzyme-linked immunosorbent assay.ResultsAfter the periodontal treatment, the glycated hemoglobin value was significantly improved. The levels of urinary N-acetyl-β-D-glucosaminidase and albumin, which are markers of renal dysfunction, also decreased significantly after treatment. Among the parameters measured in serum, the γ-glutamyl transpeptidase level, which is usually interpreted as a marker of liver dysfunction, was significantly reduced. The serum concentrations of tumor necrosis factor-α and high-sensitivity C-reactive protein were also significantly reduced by periodontal treatment.ConclusionWithin the limitations of this pilot study, periodontal treatment may be effective not only in improving metabolic control, but also in reducing the risk of diabetic kidney and liver disease in patients with T2DM.
Highlights
Studies have demonstrated that periodontal disease is associated with the development of systemic complications in patients with type 2 diabetes mellitus (T2DM)
The blood samples were analyzed for fasting plasma glucose (FPG), immunoreactive insulin (IRI), and Glycated hemoglobin (HbA1c) (National Glycohemoglobin Standardization Program [14]) by a commercial laboratory (BML Inc., Tokyo, Japan)
A recent study showed that serum high-sensitivity C-reactive protein (hs-CRP) levels were associated with a subsequent risk of developing diabetic nephropathy in type 2 diabetic patients [45]. This pilot study showed that clinically successful nonsurgical periodontal treatment improved the level of glycemic control, and the levels of NAG and albumin in the urine and γ-glutamyl transpeptidase (GGT) in the serum among various systemic disease markers
Summary
Studies have demonstrated that periodontal disease is associated with the development of systemic complications in patients with type 2 diabetes mellitus (T2DM). Some studies have demonstrated that periodontal disease is associated with the Hayashi et al BMC Oral Health (2017) 17:77 development of other systemic complications in diabetic patients, such as cardiovascular disease and renal disease [9,10,11,12] It is still unclear whether periodontal treatment influences medical status other than glycemic control in such patients. The aim of this pilot study was to investigate which markers among various systemic disease parameters are affected by periodontal treatment in patients with T2DM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
