Abstract
目的 观察己基可可碱对兔耳增生性瘢痕组织的影响.方法建立兔耳增生性瘢痕动物模型,21 d后瘢痕局部注射不同浓度的己基可可碱或生理盐水,49 d后观察药物对瘢痕增生指数(hypertrophic index,HI)的影响及采用图像系统分析瘢痕组织中成纤维细胞数量和胶原含量的变化.结果治疗组中HI与药物浓度呈负相关(P＜0.05),治疗组瘢痕组织中成纤维细胞数量与胶原含量均明显减少,呈剂量效应关系;与生理盐水对照组比较,差异有统计学意义(P＜0.01).结论己基可可碱能抑制瘢痕组织中成纤维细胞增殖,并使胶原合成减少,从而抑制兔耳增生性瘢痕组织增生,有望成为防治增生性瘢痕的新药物。
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