Effects of paternal obesity on F1 female offspring

Abstract

increase in feeding and decreased Fos activation in NPY neurons in response to ghrelin, and resistant to ghrelin injected directly into the VTA. Sucrose consumption in WT mice was similarly blunted, with significantly reduced consumption that was no longer different from KO mice, indicating that sucrose consumptionmay be sensitive to the effects of ghrelin resistance. Mice tested for ghrelin resistance in reward processing after 12 weeks on HFD did not show deficits, however, with reinstatement of increased sucrose consumption and sensitivity to intra VTA ghrelin. These findings indicate that reward pathways may remain sensitive to hormonal signals in the face of significant obesity, even when hypothalamic pathways are resistant to those signals.