Abstract
This study was designed to examine the effects of partially hydrogenated fish oil (PHFO), compared with fish oil (FO) used as a control, on serum lipids, lipoprotein profile and aortic lesion development in guinea pigs fed an atherogenic diet. Adult male Hartley guinea pigs (n=20; 10 per group) were fed a diet supplemented with 8.5 % PHFO or FO for 12 weeks. Diets contained 0.25 % cholesterol (C). The total trans fatty acid content of the PHFO diet was 4 %. PHFO‐fed animals had a significantly increased serum concentrations of triacylglycerol, total cholesterol, LDL‐C, and sdLDL‐C (P<0.001) compared with the FO group. In contrast, serum HDL‐C concentrations did not differ between the groups. Analysis of the ascending aorta and aortic arch revealed no lesion development in both treatment groups but PHFO‐fed guinea pigs showed a distinct lipid accumulation in the aortic arch when compared to the FO group. Results from this study demonstrate that guinea pigs provide a good model for studying the effects of PHFO on the lipid/lipoprotein metabolism. However, no signs of atherosclerosis in the aorta (lesion development) could be established under the used experimental conditions.
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